Policy briefing27th March 2024
Organoids are small, lab-grown three-dimensional structures that are made from stem cells to model different aspects of an organ or tissue, such as the liver, gut, kidney and brain.
This policy briefing note focuses on neural
organoids, and particularly human neural organoids, which are used to model different aspects of the developing brain.
Conclusions
- Neural organoids are promising research tools that could have important applications in the future, improving our understanding of a range of brain conditions and treatment options.
- Neural organoid research is, however, still in its infancy and its potential is yet to be fully explored. There is still uncertainty around future possibilities, research directions, likelihood of success, and the extent to which neural organoids currently resemble, and will be able to resemble, the human brain.
- Research is moving at pace, and it is difficult to predict when significant developments will take place. It is important, therefore, for policy makers to work with scientists, ethicists, and publics to ensure that the ethical and regulatory questions are fully explored, in order to ensure that appropriate guidance and regulations will be in place to facilitate innovation and address ethical considerations.
Relevant ethical considerations in neural organoid research include:
- whether or not more tailored ethical guidance and oversight is needed;
- what might be appropriate consent procedures and processes for tissue donors;
- the potential for neural organoid research to benefit human and non-human animals;
- the importance of balanced and accurate communication of neural organoids’ current and potential future capabilities; and
- the possibility of neural organoids developing capacities increasingly similar to the developing human brain, such as sentience and consciousness, if indeed they ever do.]
Areas where further ethical guidance, policy, and regulatory decisions are needed include:
- appropriate consent processes that can account for the fast-paced developments and unpredictable direction of research;
- what appropriate, future-looking, and proportionate regulation of these models might look like – if needed – considering developments in assembloids, neural organoid transplantation and other, more advanced technologies; and
- what anatomical or functional ‘hallmarks’ might be used as criteria to attribute consciousness to neural organoids and what the implications for their moral significance might be as a result