Report27th November 2024

Human stem cell-based embryo models: A review of ethical and governance questions

The report sets out a road map for current and future governance of the fast-moving field of research using human stem cell-based embryo models (SCBEMs).

Reproduction, parenthood & familiesEmbryo and stem cell research

Report (PDF)Policy briefing (PDF)

This report provides an overview of the science, ethics and regulatory landscape surrounding research involving human stem cell-based embryo models (SCBEMs).

SCBEM is an umbrella term for a range of structures created from stem cells which
resemble or replicate aspects of embryonic development. These stem cells are
derived either from embryos (embryonic stem cells – ESCs) or through the
reprogramming of cells from other human tissue such as skin or blood cells (induced pluripotent stem cells – iPSCs).

As a research tool, SCBEMs have the potential to bring public benefit through new insights around early human development. However, there is debate about their status – for example in relation to human embryos – and how they should be used.

Our recommendations offer a useful resource to policymakers, scientists and research funders navigating this fast-moving area of scientific research.

This report shares the findings of our rapid review undertaken in 2024, overseen by an expert working group.