Terms of reference

1. To explore what pharmacogenetics offers now and is likely to offer in the near future;

In particular to examine the effect of pharmacogenetics on:

a) the design of medicines, the promotion of efficacy and safety in the administration of medicines to individuals;
b) the conduct of clinical trials in the context of pharmaceutical research and development;
c) clinical practice.

2. To consider ethical issues specifically raised by pharmacogenetics;

In particular to examine the following areas:

a) consent, privacy and confidentiality;
b) the management of information about the likelihood of response to treatment;
c) the implications of differentiating individuals into groups based on the likelihodd of response to treatment.

3. To consider the implications for the provision of healthcare.

Previous work

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Nuffield Council on Bioethics
28 Bedford Square
London
WC1B 3JS

bioethics@nuffieldbioethics.org

+44 (0)20 7681 9619

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